Article

Amyotrophic lateral sclerosis (ALS) is an idiopathic, fatal neurodegenerative
disease of the human motor system. In this Seminar, we summarise current concepts
about the origin of the disease, what predisposes patients to develop the
disorder, and discuss why all cases of ALS are not the same. In the 150 years
since Charcot originally described ALS, painfully slow progress has been made
towards answering these questions. We focus on what is known about ALS and where
research is heading-from the small steps of extending longevity, improving
therapies, undertaking clinical trials, and compiling population registries to
the overarching goals of establishing the measures that guard against onset and
finding the triggers for this neurodegenerative disorder.
CI - Copyright (c) 2011 Elsevier Ltd. All rights reserved.

Langue : ANGLAIS

Tiré à part : OUI