Article

Healthy adult joint cartilage contains neither blood vessels nor nerves.
Osteoarthritic cartilage, in contrast, may be invaded by blood vessels from the
subchondral bone. The mechanisms underlying cartilage angiogenesis in
osteoarthritis are unclear but may involve hypertrophic chondrocyte
differentiation. Active research is under way to identify the factors involved in
cartilage angiogenesis. Here, we discuss the pathophysiological mechanisms of
osteoarthritic cartilage angiogenesis based on evidence from a systematic
literature review of articles retrieved via PubMed and ISI Web of Knowledge. Our
conclusions suggest new research perspectives and treatment options.
CI - Copyright (c) 2010 Societe francaise de rhumatologie. Published by Elsevier SAS.
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Langue : ANGLAIS