Article

OBJECTIVE: To evaluate the effects of a single transrectal ultrasound
(TRUS)-guided transperineal injection of botulinum toxin A (BTX-A) to the
external urethral sphincter (EUS) for treating detrusor external sphincter
dyssynergia (DESD). DESIGN: Descriptive study. SETTING: Rehabilitation hospital
affiliated with a medical university. PARTICIPANTS: Patients (N=18) with
suprasacral spinal cord injury who had DESD confirmed on video-urodynamic study.
INTERVENTIONS: A single dose of 100U BTX-A was applied into the EUS via
TRUS-guided transperineal route injection. MAIN OUTCOME MEASURES: Maximal
detrusor pressure, detrusor leak-point pressure, integrated electromyography
(iEMG), maximal pressure on static urethral pressure profilometry, and
postvoiding residuals. RESULTS: There were significant reductions in iEMG
(P=.008) and static (P=.012) and dynamic urethral pressure (P=.023), but not in
detrusor pressure and detrusor leak-point pressure after treatment. Postvoiding
residuals also significantly decreased in the first and second month after
treatment (P<.012). CONCLUSIONS: TRUS-guided transperineal injection of BTX-A has
beneficial effects in treating DESD.
CI - Copyright 2010 American Congress of Rehabilitation Medicine. Published by
Elsevier Inc. All rights reserved.

Langue : ANGLAIS