Article

Recent advances in genomics, proteomics, and biotechnology have provided
unprecedented opportunities for translational research and personalized medicine.
Human biospecimens and biofluids represent an important resource from which
molecular data can be generated to detect and classify injury and to identify
molecular mechanisms and therapeutic targets. To date, there has been
considerable variability in biospecimen and biofluid collection, storage, and
processing in traumatic brain injury (TBI) studies. To realize the full potential
of this important resource, standardization and adoption of best practice
guidelines are required to insure the quality and consistency of these specimens.
The aim of the Biospecimens and Biomarkers Working Group was to provide
recommendations for core data elements for TBI research and develop best practice
guidelines to standardize the quality and accessibility of these specimens.
Consensus recommendations were developed through interactions with focus groups
and input from stakeholders participating in the interagency workshop on
Standardization of Data Collection in TBI and Psychological Health held in
Washington, DC, in March 2009. With the adoption of these standards and best
practices, future investigators will be able to obtain data across multiple
studies with reduced costs and effort and accelerate the progress of genomic,
proteomic, and metabolomic research in TBI.
CI - Published by Elsevier Inc.

Langue : ANGLAIS