Article

Aim of this work was to study the postoperative pain within the first week of a
total knee replacement by comparing three different forms of administration of
analgesia. We proposed to verify the correspondence between a subjective pain
assessment made by the patient on a Visual Analogic Scale (VAS) and an objective
assessment made by assaying the serum algogenic cytokines interleukin-1 (IL1),
interleukin-6 (IL6), and tumor necrosis factor-alpha (TNF-alpha). Statistical
analysis of the data on the VAS and the three cytokine assays done preoperatively
and on the third and seventh days postoperatively showed that while the VAS
declined progressively postoperatively, IL6 tended to be higher on the third
postoperative day and then lower on the seventh. The other two cytokines showed
no differences preoperatively and postoperatively. On the basis of our results,
we support the validity of IL6 dosage to monitor the postoperative pain during
future studies.

Langue : ANGLAIS