Article

OBJECTIVES: To investigate the association between bone mineral density (BMD) and
muscle strength in survivors of childhood acute lymphoblastic leukemia (ALL), a
population at increased risk for both decreased BMD and muscle strength from
cancer and its treatment. DESIGN: Cohort data from the St Jude Lifetime Cohort
(SJLIFE) study. SETTING: Department of Cancer Control at St Jude Children's
Research Hospital. PARTICIPANTS: Subjects were adults enrolled in St Jude
Lifetime Cohort study and treated for childhood ALL between 1962 and 1999. As
part of a comprehensive evaluation, participants had dual energy x-ray
absorptiometry (DEXA) scans and muscle strength testing. The participants
consisted of 261 women and 232 men who were 20.4 to 49.8 years old (median,
35.7y), and 12.7 to 46.5 years from diagnosis of childhood ALL (median, 27.2y).
INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURES: BMD was determined by DEXA
scan. Muscle strength of upper and lower extremities was assessed with physical
performance testing. RESULTS: After adjusting for covariates, we found
significant (P<0.005) associations between BMD and muscle strength in lower
extremities (R(2) range, 0.33-0.40) and strong, significant associations in upper
extremities (left-side R(2)=0.558; right-side R(2)=0.560). CONCLUSIONS: Muscle
strength was associated with BMD in the extremities of long-term survivors of
childhood ALL, a finding suggesting that muscle strengthening interventions may
improve bone health in them.
CI - Copyright (c) 2011 American Congress of Rehabilitation Medicine. Published by
Elsevier Inc. All rights reserved.

Langue : ANGLAIS