Article

The aim of this study was to understand the meaning of the double-peak
responses in digital nerve conduction study in normal and diabetic patients.
DESIGN: This was a cross-sectional and correlative study. Sixty healthy subjects
(10 people per decade from 20 to 79 yrs of age; 26 men; mean age, 48 yrs) and 60
diabetic patients (10 people per decade from 22 to 79 yrs of age; 36 men, mean
age, 53 yrs) were included. The composite score of the nerve conduction study was
obtained. Orthodromic sensory nerve conduction studies were performed on the
median nerves using submaximal stimulation. The latencies and amplitudes of first
and second peaks were measured. The Toronto clinical scoring system for diabetic
neuropathy was applied to all diabetic patients. RESULTS: The first and second
peak latencies of both 3- and 4-cm interpeak distance in diabetic patients were
significantly increased compared with those of age-matched control subjects (P <
0.05). The correlation between the Toronto clinical scoring system and first and
second peak latency and amplitude were significantly high, and the correlation
between the composite score and first and second peak latency and amplitude was
also related. CONCLUSIONS: The double-peak response represents the far distal
nerve pathophysiology. The authors suspect that they will find an increasing role
in diagnosing the peripheral neuropathy, which starts at the distal nerve in
centripetal pattern.

Langue : ANGLAIS