Article

AIM: To determine whether post-injury depressive symptoms, and pre-injury major
life stressors and genetic factors (HTR1A C(-1019)G alleles; rs6295) are more
common in children with mild traumatic brain injury (mTBI) who develop
postconcussion syndrome (PCS) symptoms compared with children with asymptomatic
mTBI. METHOD: This was a cross-sectional study of 47 symptomatic children (32
males, 15 females; mean age 14y [SD 3y 3mo]) who experienced post-concussive
symptoms for 7 or more days and 42 asymptomatic children (26 males 16 females;
mean age 13y 6mo [SD 3y 1mo]) after mTBI. Outcome measures were the
Postconcussion Symptoms Inventory (PCSI), the Children's Depression Inventory
(CDI), standard questionnaire of previous life events, and buccal DNA analysis to
determine genotype and allele frequencies for the HTR1A C(-1019)G polymorphism.
RESULTS: Depressive symptoms were uncommon. CDI scores did not differ between
groups. Allelic and genotypic frequencies for HTR1A C(-1019)G were similar in
both groups. Symptomatic children continued to have elevated PCS scores compared
with asymptomatic children 1.72 (SD 0.69) years later and had experienced
significantly more life stressors (Wald (1)=8.51, p=0.004). INTERPRETATION: HTR1A
polymorphisms do not differ in children with PCS. Children who have experienced
more significant life stresses are more likely to develop PCS symptoms after
mTBI.
CI - (c) 2013 Mac Keith Press.

Langue : ANGLAIS