Article

The aim of this study was to evaluate the role of levodopa/carbidopa
as an augmenting agent to improve motor recovery after brain tumor excision.
This case report is structured as an n-of-1 style trial. The study
patient was an outpatient with residual hemiparesis secondary to removal of
benign oligoastrocytoma seen in an outpatient physiatry practice at an academic
center. The study intervention was levodopa/carbidopa vs. placebo, combined with
a structured 6-wk physiotherapy regimen. Outcomes were measured using the motor
subscale of the Fugl-Meyer Assessment to assess for motor recovery. RESULTS: The
mean motor Fugl-Meyer Assessment score for the levodopa/carbidopa weeks was 6.90
points greater than the mean score for placebo. The results were significant at P
< 0.05. CONCLUSIONS: Levodopa/carbidopa may have a beneficial effect on improving
motor recovery after sustaining a brain injury as a result of tumor excision.

Langue : ANGLAIS