Article

Osteochondral lesions of the knee (OLK) are a common cause of knee pain and
associated diseases.
A new bone-marrow-derived mesenchymal stem cells technique
has been developed for the treatment of OLK. 30 patients with OLK underwent
arthroscopic one-step procedure. The bone marrow was harvested from the patients'
posterior iliac crest and arthroscopically implanted with a scaffold into the
lesion site. Clinical inspection and MRI were performed. Mean International Knee
Documentation Committee (IKDC) score before surgery was 29.9 +/- 13.2 and 85.4
+/- 4.2 at 29 +/- 4.1 months (p < 0.0005), while Knee injury and Osteoarthritis
Outcome Score (KOOS) before surgery was 35.1 +/- 11.9 and 87.3 +/- 7.3 at 29 +/-
4.1 months (p < 0.0005).
Control MRI and bioptic samples showed an osteochondral
regeneration of the lesion site. The one-step technique appears to be a good and
reliable option for treatment of OLK at three years of follow-up. Level of evidence Case series, Level IV.

Langue : ANGLAIS