Article

OBJECTIVE: To examine the impact of a muscle resistance program (MRP) on muscular
and functional performance and on interleukin 6 (IL-6) and soluble tumor necrosis
factor receptor-1 (sTNFr1) plasma levels in prefrail community-dwelling women.
DESIGN: Randomized controlled trial crossover design with a postintervention and
short-term follow-up.
SETTING: University hospital. PARTICIPANTS: Prefrail
community-dwelling women (N=32; >/=65y). INTERVENTION:
The MRP was designed based
on the exercise at 75% of each participant's maximum load (10wk, 3 times/wk).
MAIN OUTCOME MEASURES: Plasma concentrations of IL-6 and sTNFr1 (high-sensitivity
enzyme-linked immunosorbent assay kits), muscle strength of the knee extensors
(isokinetic), and functional performance (Timed Up & Go [TUG] test and 10-meter
walk test [10MWT]). RESULTS: There were significant differences in functional and
muscular performance between the pre-MRP, post-MRP, and 10-week follow-up period.
After the MRP, both functional (TUG, pre-MRP=11.1s vs post-MRP=10.4s, P=.00;
10MWT, pre-MRP=4.9s vs post-MRP, 4.4s, P=.00) and muscular performances
(pre-MRP=77.8% and post-MRP=83.1%, P=.02) improved. After cessation of the MRP
(follow-up period), sTNFr1 plasma levels increased by 21.4% at 10-week follow-up
(post-MRP, 406.4pg/mL; 10-week follow-up, 517.0pg/mL; P=.03). There were
significant differences in sTNFr1 (P=.01). CONCLUSIONS:
The MRP was effective in
improving functional and muscular performances, although alterations in plasma
levels of IL-6 and sTNFr1 could not be identified after the MRP. Cessation of the
MRP after 10 weeks resulted in increased plasma levels of sTNFr1.
CI - Copyright (c) 2013 American Congress of Rehabilitation Medicine. Published by
Elsevier Inc. All rights reserved.

Langue : ANGLAIS