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Evolution of life expectancy of patients with Duchenne muscular dystrophy at AFM Yolaine de Kepper centre between 1981 and 2011 = Evolution de l'espérance de vie des patients atteints de dystrophie musculaire de Duchenne au Centre AFM Yolaine de Kepper entre 1981 et 2011

KIENY P; CHOLLET S; DELALANDE P; LE FORT M; MAGOT A; PEREON Y; PERROUIN VERBE B
ANN PHYS REHABIL MED , 2013, vol. 56, n° 6, p. 443-454
Doc n°: 165000
Localisation : Documentation IRR

D.O.I. : http://dx.doi.org/DOI:10.1016/j.rehab.2013.06.002
Descripteurs : AB311 - MYOPATHIE DE DUCHENNE DE BOULOGNE

Retrospective study over the last 30years of life expectancy in
patients suffering from Duchenne muscular dystrophy (DMD). Analysis of the role
of ventilatory assistance and causes of death. METHODS: One hundred
and nineteen adult DMD patients were hosted during 1981 to 2011 at AFM Yolaine de
Kepper centre, Saint-Georges-sur-Loire, France. Patients' life expectancy was
calculated using Kaplan-Meier model. RESULTS: Life expectancy without or with
ventilatory assistance was 22.16 and 36.23years, respectively. Similarly, life
expectancy of patients born from 1970 (mostly with ventilatory assistance) was
40.95years old from 1970 and 25.77years old before 1970. Causes of death changed.
Cardiac origins of death have increased from 8% to 44%. CONCLUSION: Ventilator
assistance, in this study mostly through tracheotomy prolongs by more than 15
years life expectancy of DMD patients. It allows conservation of a satisfactory
quality of life, and should be systematically proposed to patients.
CI - Copyright (c) 2013 Elsevier Masson SAS. All rights reserved.

Langue : ANGLAIS ; FRANCAIS

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