Article

Language disorders of degenerative origin are frequently tied to Alzheimer
disease (AD) the different variants of which can result in primary and secondary
aphasia syndromes. More specifically, Alzheimer pathology can primarily erode
frontal, temporal or parietal language cortices resulting in three genuine AD
language variants which account for about 30% of primary degenerative aphasias.
Likewise, it can spread from non-language to language cortices leading to
secondary language disorders like in typical amnesic AD and in several atypical
AD variants. This paper reviews the whole set of AD variants by characterising
their impact on the neural language system and on linguistic functioning. It also
provides cues for diagnostic strategies which are essential for linguistic,
syndromic and nosological patient classification, for adequate clinical follow-up
and for guiding language rehabilitation. Such diagnostic approaches, founded on
detailed linguistic phenotyping while integrating anatomical and
neuropathological findings, also represent a crucial issue for future drug trials
targeting the physio-pathological processes in degenerative aphasias.
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Langue : ANGLAIS