Article

Metabolic and deficiency neuropathies retain a growing interest because of their
important prevalence. The dismemberment of diabetic neuropathies is proceeded,
letting distinct pathophysiological mechanisms appear. So, even if glycaemic
control remains determining for preventing the neuropathy associated with type 1
diabetes, it seems to have a restricted role with type 2 diabetes in which other
metabolic factors are involved. The diagnosis of neuropathy due to B12 vitamin
deficiency remains a real challenge for the clinician. Indeed, positive and
negative predictive values of serum B12 and metabolites assay are weak, only a
good therapeutic response allows a reliable diagnostic. It is so recommended to
know the clinical and contextual particularities of this etiology in order to not
delay the vitamin substitution, determining for the functional outcome. Finally,
copper deficiency remains an unknown cause of neuropathy which is suitable to
raise in case of malabsorption but also and especially in case of abuse of dental
adhesive rich in zinc.
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Langue : FRANCAIS