Article

Today, administering rTPA thrombolytic therapy within the first hours of a stroke
is the only validated drug therapy for improving the spontaneous - and most of
the time incomplete - recovery of neurological functions post-stroke. However in
the past decade, thanks in part to the considerable advances of neuroimaging
techniques, we have learned that spontaneous recovery of neurological functions
was associated with a wide intracerebral reorganization of the damaged human
brain. The question of whether lesioned-brain plasticity can be modulated by
external factors like pharmacological agents is now addressed in the hope of
improving recovery and reducing the chronic impairments of stroke patients. In
this paper, we review the preclinical and clinical evidence for a direct action
of SSRIs in promoting recovery in ischemic stroke patients.
CI - Copyright (c) 2014. Published by Elsevier Masson SAS.

Langue : ANGLAIS ; FRANCAIS