Article

The application of regenerative strategies to musculoskeletal ailments offers
extraordinary promise to transform management of the conditions of numerous
patients. The use of cell-based therapies and adjunct strategies is under active
investigation for injuries and illnesses affecting bones, joints, tendons, and
skeletal muscle. Of particular interest to the field is the mesenchymal stem
cell, an adult stem cell found in bone marrow and adipose tissue. This cell type
can be expanded ex vivo, has allogeneic application, and has the capacity for
engraftment and differentiation into mesodermal lineages. Also of major interest
in the field is the use of platelet-rich plasma, a strategy to concentrate
endogenous cytokines and growth factors with reparative potential. Here we review
the biological basis, clinical studies, safety, and current state of mesenchymal
stem cell and platelet-rich plasma therapies in the treatment of musculoskeletal
disease.
CI - Copyright (c) 2014 American Academy of Physical Medicine and Rehabilitation.
Published by Elsevier Inc. All rights reserved.

Langue : ANGLAIS