Article

OBJECTIVE: To ascertain the effect of arm cranking exercise on improving plasma
levels of inflammatory cytokines and adipokines in untrained adults with chronic
spinal cord injury (SCI). DESIGN: Longitudinal study. SETTING: Community-based
supervised intervention. PARTICIPANTS: Men (N=17) with complete SCI at or below
T5 volunteered for this study. Participants were randomly allocated to the
intervention (n=9) or control group (n=8) using a concealed method. INTERVENTION:
A 12-week arm cranking exercise program of 3 sessions per week consisted of
warm-up (10-15min), arm crank (20-30min; increasing 2min and 30s every 3wk) at a
moderate work intensity of 50% to 65% of heart rate reserve (starting at 50% and
increasing 5% every 3wk), and cool-down (5-10min). MAIN OUTCOME MEASURES: Plasma
levels of leptin, adiponectin, plasminogen activator inhibitor-1, tumor necrosis
factor-alpha, and interleukin-6 were determined. Furthermore, physical fitness
(maximum oxygen consumption [V O2max]) and body composition (anthropometric
index, waist circumference, and body mass index) were also assessed. RESULTS:
Plasma levels of leptin, tumor necrosis factor-alpha, and interleukin-6 were
significantly decreased after the completion of the training program. Similarly,
the anthropometric index and waist circumference were diminished too. A moderate
correlation was found between leptin and the anthropometric index. Finally, V
O2max was significantly increased, suggesting an improvement of physical fitness
in the intervention group. No changes were found in the control group.
CONCLUSIONS: Arm cranking exercise improved low-grade systemic inflammation by
decreasing plasma levels of inflammatory cytokines. Furthermore, it also reduced
plasma leptin levels. Long-term, well-conducted studies are still required to
determine whether these changes may improve clinical outcomes of adults with
chronic SCI.
CI - Copyright (c) 2014 American Congress of Rehabilitation Medicine. Published by
Elsevier Inc. All rights reserved.

Langue : ANGLAIS