Article

OBJECTIVE: To assess the effect of a 12-week arm-cranking exercise program on
reducing oxidative damage in untrained adults with chronic spinal cord injury
(SCI). DESIGN: Randomized controlled trial. SETTING: Community-based supervised
intervention. PARTICIPANTS: Male adults with complete SCI at or below the fifth
thoracic level (T5) (N=17) volunteered for this study. Participants were randomly
allocated to the intervention (n=9) or control (n=8) group using a concealed
method. INTERVENTION: A 12-week arm-cranking exercise program, 3 sessions/wk,
consisting of warming-up (10-15min) followed by a main part in arm-crank
(20-30min [increasing 2min and 30s every 3wk]) at a moderate work intensity of
50% to 65% of the heart rate reserve (starting at 50% and increasing 5% every 3
weeks) and by a cooling-down period (5-10min). MAIN OUTCOME MEASURES: Plasmatic
levels of total antioxidant status as well as erythrocyte glutathione peroxidase
activity were measured. Lipid and protein oxidation were determined as
malondialdehyde and carbonyl group levels, respectively. Furthermore, physical
fitness and body composition were assessed. RESULTS: When compared with baseline
results, maximum oxygen consumption was significantly increased (P=.031),
suggesting an improvement in physical fitness in the intervention group.
Regarding the antioxidant defense system, it was found that both total
antioxidant status (P=.014) and erythrocyte glutathione peroxidase activity
(P=.027) were significantly increased at the end of the training program. As a
consequence, plasmatic levels of malondialdehyde (P=.008) and carbonyl groups
(P=.022) were significantly reduced. CONCLUSION: A 12-week arm-cranking exercise
program improved the antioxidant defense system in adults with chronic SCI, which
may finally attenuate both lipid and protein oxidation in this population.
CI - Copyright (c) 2013 American Congress of Rehabilitation Medicine. Published by
Elsevier Inc. All rights reserved.

Langue : ANGLAIS