Article

OBJECTIVE: To investigate the relations between Medical Research Council (MRC)
dyspnea grade and peripheral muscle force, activities of daily living (ADL)
performance, health status, lung function, and exercise capacity in subjects with
idiopathic pulmonary fibrosis (IPF). DESIGN: Prospective cross-sectional
observational study. SETTING: University hospital. PARTICIPANTS: Subjects with
IPF (N=65, 46 men) in a stable clinical state with a mean age of 68+/-7 years.
INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURES: Right ventricular systolic
pressure (RVSP) via transthoracic echocardiography, pulmonary function, isometric
quadriceps force (QF) and handgrip force (HF), 6-minute walk distance (6MWD), ADL
score, and health status (Medical Outcomes Study 36-Item Short-Form Health Survey
[SF-36]) were assessed and compared between subjects grouped according to MRC
grade. RESULTS: Of the participants, 16 were in MRC grade 2, 17 were in MRC grade
3, 17 were in MRC grade 4, and 15 were in MRC grade 5. RVSP, pulmonary function,
QF, HF, 6MWD, ADL, and SF-36 scores decreased with increasing MRC grade (all
P<.001). All measures were lower (P<.05) in subjects with grades 4 and 5 than
subjects with grades 2 and 3. Strong associations were found between MRC grade
and 6MWD (rho=-.89, P=.001) and ADL score (rho=-.82, P=.001). MRC grade was also
associated with RVSP, pulmonary function, QF, and HF (all rho>/=.56, P=.001).
CONCLUSIONS: The MRC dyspnea scale provides a simple and useful method of
categorizing individuals with IPF with respect to their activity limitation and
may assist in understanding the impact of IPF on an individual.
CI - Copyright (c) 2014 American Congress of Rehabilitation Medicine. Published by
Elsevier Inc. All rights reserved.

Langue : ANGLAIS