Article

The aim of this study was to identify whether there were
any strength differences between DM1 patients who were habitually active or
sedentary. DESIGN: Knee extension, handgrip, and elbow flexion quantitative
strength measurements were investigated in the DM1 patients using isokinetic
dynamometry. Strength was compared between the patients who followed
self-selected formal exercise plans for at least 1 yr, those who were sedentary
(controls), and those who initiated or terminated a formal exercise routine.
RESULTS: Physically active DM1 patients with midrange CTG repeat size (100-500
CTG repeat sizes) had significantly stronger handgrip and knee extension and
elbow flexion torques as compared with their sedentary counterparts with the same
CTG repeat range. The DM1 patients who began a formal exercise routine
experienced a significant improvement in knee extension torque measurements
(+24.3%) in comparison with those who were habitually active or sedentary.
CONCLUSIONS: These data suggest that there is an association between physical
activity and strength. This may be shown to be a useful tool for the management
of this condition. Further investigations into the relationships between physical
exercise, muscle weakness, and genetic factors are needed before evidence-based
recommendations can be made.

Langue : ANGLAIS