Article

Parkinson's disease (PD) differs from atypical parkinsonism in many
clinical aspects. Principally, posture and gait are distinct features in the
early stages of the disease; thus, these differences can be helpful in differential diagnosis. METHODS: We analyzed videos of patients with PD or
atypical parkinsonism. A total of 76 patients with early PD (n=56) or atypical
parkinsonism (n=20) were included. Items related to posture and gait were
classified into three categories (standing, gait and associated symptoms) and
each sub-item was analyzed. RESULTS: Asymmetric arm-swing (p=0.004) and
accompanying tremor (p=0.016) were significant indicators of early-stage PD.
Staggering gait (p=0.007) and en-bloc turning (p=0.026) were more common in
atypical parkinsonism. Characteristics with a high odds-ratio for atypical
parkinsonism were en-bloc turning (beta=8.475, p=0.032) and normal arm-swing
(beta=14.6084, p=0.036). CONCLUSIONS: Visual inspection of gait and posture
provides reliable clues in the differential diagnosis of parkinsonism.
CI - Copyright (c) 2014 Elsevier B.V. All rights reserved.

Langue : ANGLAIS