Article

OBJECTIVE: To examine whether acute inflammation profiles predict posttraumatic
depression (PTD) risk 6 and 12 months after traumatic brain injury. SETTING:
University-affiliated level 1 trauma center and community. PARTICIPANTS: Adults
with moderate to severe traumatic brain injury (acute serum levels: n = 50; acute
cerebrospinal fluid (CSF) levels: n = 41). DESIGN: Prospective cohort study. MAIN
MEASURES: Patient Health Questionnaire; inflammatory biomarkers (interleukin
[IL]-1beta, IL-4, IL-5, IL-6, IL-7, IL-8, IL-10, IL-12, tumor necrosis factor
alpha, soluble vascular adhesion molecule [sVCAM-1], soluble intracellular
adhesion molecule [sICAM-1], soluble Fas [sFAS]). RESULTS: Higher levels of acute
CSF cytokine surface markers (sVCAM-1, sICAM-1, and sFAS) in an inflammatory
biomarker risk (IBR) score were associated with a 3.920-fold increase in the odds
of developing PTD at 6 months (95% confidence interval: 1.163-8.672). Having
sICAM-1, sVCAM-1, or sFAS above the 75th percentile had a positive predictive
value of 85.7% for PTD risk at 6 months. An IBR score including inflammatory
biomarkers IL-7 and IL-8 showed a trending association with 12-month PTD risk
(odds ratio = 3.166, 95% confidence interval: 0.936-10.708). CONCLUSION: Acute
CSF IBR scores show promise for identifying individuals at risk for PTD. Further
research should assess acute CSF inflammatory biomarkers' relationships to
chronic inflammation as a mechanism of PTD and should explore anti-inflammatory
treatments for PTD, as well as prevention and screening protocols, and link
inflammatory biomarkers to symptom tracking.

Langue : ANGLAIS