Article

Evidence of nonopioid analgesic effectiveness exceeds that for long-term opioids
in chronic noncancer pain (CNCP), most with lower risk. Non-drug therapies such
as cognitive behavioral therapy and physical activation are safer and also
effective. Nonsteroidal antiinflammatory drugs are useful for inflammatory and
nociceptive pain, share renal and variable gastrointestinal, bleeding and
cardiovascular side effects. Antidepressants with noradrenergic activity (such as
tricyclics and seroton-norepinephrine reuptake inhibitors) and neuromodulating
anticonvulsant drugs (gabapentinoids and sodium-channel blockers) are proven to
be effective for neuropathic and centralized pain. Ketamine and cannabinoids are
other studied analgesics but have a less well-proven role in CNCP.
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Langue : ANGLAIS