Article

AIM: To determine whether racial disparities in cerebral palsy (CP) risk among US
children persist after controlling for socio-economic status (SES) (here
indicated by maternal education) and perinatal risk factors. METHOD: A
population-based birth cohort study was conducted using the Autism and
Developmental Disabilities Monitoring Network surveillance and birth data for
8-year-old children residing in multi-county areas in Alabama, Georgia, Missouri,
and Wisconsin between 2002 and 2008. The birth cohort comparison group included
458 027 children and the case group included 1570 children with CP, 1202 with
available birth records. chi(2) tests were performed to evaluate associations and
logistic regression was used to calculate relative risks (RR) and adjusted odds
ratios (OR) with 95% confidence intervals (CI). RESULTS: The risk of spastic CP
was more than 50% higher for black versus white children (RR 1.52, 95% CI
1.33-1.73), and this greater risk persisted after adjustment for SES (OR 1.35,
95% CI 1.18-1.55), but not after further adjustment for preterm birth and size
for gestational age. The protective effect of maternal education remained after
adjustment for race/ethnicity and perinatal factors. INTERPRETATION: Maternal
education appears to independently affect CP risk but does not fully explain
existing racial disparities in CP prevalence in the US.
CI - (c) 2015 Mac Keith Press.

Langue : ANGLAIS