Article

In a population cohort of children with grey matter injury (GMI) and
cerebral palsy (CP), we aimed to describe and classify magnetic resonance imaging
characteristics specific to GMI, and to identify key structure-function
associations that serve as a basis for rating GMI in clinically relevant ways.
METHOD: Symmetry, extent of cerebral injury, and pathological pattern for 54
children (37 males, 17 females) with CP and a predominant GMI pattern on
chronic-phase magnetic resonance imaging were related to gross motor function,
motor type and topography, epilepsy, intellectual disability, blindness, and
deafness. RESULTS: Relative to mild GMI where there was no pallidal abnormality,
severe GMI, comprising pallidal abnormality alone or in conjunction with other
deep nuclear and generalized cortical-subcortical involvement, was strongly
associated with Gross Motor Function Classification System levels IV to V (OR
35.7 [95% CI 3.5, 368.8]). Involvement of the basal ganglia was associated with
non-spastic/mixed motor types, but predominantly where cortical-subcortical grey
and white matter involvement was not extensive. The prevalence of epilepsy was
highest where there was diffuse cortical-subcortical involvement and white matter
loss. INTERPRETATION: Better understanding of structure-function relationships in
CP and GMI, and how to rate the severity of GMI, will be helpful in the clinical
context and also as a basis for investigation of causal pathways in CP.
CI - (c) 2015 Mac Keith Press.

Langue : ANGLAIS