Article

OBJECTIVE: To investigate the effect of reducing spasticity via onabotulinumtoxin
A (Obtx-A) injection on cerebellar activation after chronic stroke during
unilateral gripping.
DESIGN: Pre-post, case series.
SETTING: Outpatient
spasticity clinic. PARTICIPANTS: Individuals with chronic spasticity (N=4).
INTERVENTIONS: Upper-limb Obtx-A injection. MAIN OUTCOME MEASURES: Functional
magnetic resonance imaging (fMRI) was used to measure changes in cerebellar
activation before and after upper-limb Obtx-A injection. During fMRI testing,
participants performed the same motor task before and after injection, which was
15% and 30% of maximum voluntary isometric gripping measured before Obtx-A
injection. RESULTS: After Obtx-A injection, cerebellar activation increased
bilaterally during gripping with the paretic hand and during rest. During both
pre- and postinjection scans, the paretic hand showed larger cerebellar
activation during gripping compared with the nonparetic hand. Cerebellar
activation during gripping with the nonparetic hand did not change significantly
after Obtx-A injection. CONCLUSIONS: Reducing spasticity via Obtx-A injection may
increase cerebellar activation both during gripping tasks with the paretic hand
and during rest. To our knowledge, this is the first study that examines changes
in cerebellar activation after spasticity treatment with Obtx-A.
CI - Copyright (c) 2015 American Congress of Rehabilitation Medicine. Published by
Elsevier Inc. All rights reserved.

Langue : ANGLAIS