Article

OBJECTIVE: To determine sex differences in the recovery and prognosis after mild
traumatic brain injury (MTBI) in adults and children. DATA SOURCES: We analyzed
all scientifically admissible primary studies in the World Health Organization
(WHO) (n=120) and International Collaboration on Mild Traumatic Brain Injury
Prognosis (ICoMP) (n=101) systematic reviews regarding prognosis of MTBI for
sex-stratified findings. They searched MEDLINE and other databases from 1980
through 2000 (WHO) and 2001 through 2012 (ICoMP) for published, peer-reviewed
reports in English and other languages. STUDY SELECTION: We selected controlled
trials and cohort and case-control studies that assessed the effect of sex on
outcomes after MTBI. DATA EXTRACTION: Data from the eligible studies from both
systematic reviews combined
(n=14, 7%) were extracted into evidence tables. DATA
SYNTHESIS: Prognostic information relating to sex was prioritized according to
design as exploratory or confirmatory, and a best-evidence synthesis was
conducted. After MTBI, females may have a higher risk of epilepsy (children,
young adults) and suicide, and use more health care services; males may be at
higher risk for schizophrenia. Most studies did not find a sex difference for
postconcussion symptoms in children and adults. No sex difference was found for
risk of dementia and primary brain tumor, return to work, or posttraumatic stress
syndrome. CONCLUSIONS: Sex is not a well-studied prognostic indicator for
recovery after MTBI, but small sex differences were found for some outcomes. More
well-designed studies are needed that report outcomes according to sex and
control for potential confounders.
CI - Copyright (c) 2016 American Congress of Rehabilitation Medicine. Published by
Elsevier Inc. All rights reserved.

Langue : ANGLAIS