Article

There has been a greater appreciation of several variables obtained
by cardiopulmonary exercise testing (CPX). Exercise oscillatory ventilation (EOV)
is a CPX pattern that has gained recognition as an ominous marker of poor
prognosis in cardiac patients. The purpose of the present study is to
characterize whether such an abnormal ventilatory pattern may also be detected in
apparently healthy subjects and determine its clinical significance. METHODS: The
study involved 510 subjects (mean age 60 +/- 14 years; 49% male) with a broad
cardiovascular (CV) risk factor profile who underwent CPX. RESULTS: The
population was divided into two groups according to the presence (17%) or absence
of EOV. Subjects with EOV were significantly older and a higher percentage was
female. Risk factor profile and medication use was significantly different
between subgroups, indicating subjects with EOV had a worse CV risk factor
profile and were prescribed CV-focused preventive medications at a significantly
higher frequency. Subjects with EOV had comparatively poorer CPX performance and
gas exchange phenotype. Multivariate binary logistic regression analysis found
being female was the strongest predictor of EOV (odds ratio: 2.77, 95% confidence
interval (CI): 1.66-4.61, p < 0.001). A diagnosis of diabetes (odds ratio: 2.40,
95% CI: 1.34-4.15.2, p < 0.001) added significant value for predicting EOV and
was retained in the regression. The likelihood for EOV for subjects who were
female and diagnosed with diabetes was 3.71 (95% CI 1.88-7.30, p < 0.001).
CONCLUSIONS: This is the first study to examine EOV prevalence and
characterization in apparently healthy persons with results supporting an
in-depth definition of abnormal exercise phenotypes.
CI - (c) The European Society of Cardiology 2015.

Langue : ANGLAIS