Article

Statin treatment in association with physical exercise can
substantially reduce mortality in dyslipidaemic individuals. However, the
available data to compare the efficacy and safety of statins and exercise
combination therapy with statin monotherapy are limited. Design Systematic review
and meta-analysis. Methods We systematically searched PubMed, Embase and the Cochrane Library from database inception until December 2016.
We included
randomised and non-randomised studies that compared the efficacy and safety of
statins and exercise combination therapy with statin monotherapy in patients with
dyslipidaemia. Standardised mean differences were calculated and pooled by means
of fixed effects models.
The risk of bias and heterogeneity among trials was also
assessed. Seven articles were assessed in terms of the efficacy of therapy and 13
from the viewpoint of therapeutic safety. Results In terms of efficacy, statins
and exercise combination decreased the incidence of diabetes mellitus, improved
insulin sensitivity and inflammation, but caused no change in lipid profile
compared to statins alone. In terms of safety, statins and exercise combination
increased peak oxygen uptake (standardised mean difference 1.01, 95% confidence
interval 0.46 to 1.57) compared to statins alone. In contrast to statin-induced
myopathy, chronic exercise training prior to statin treatment could counteract
statin-induced adverse effects in skeletal muscle.
Conclusion Statins and
exercise combination therapy is more effective than statin monotherapy in terms
of insulin sensitivity, inflammation and exercise capacity.
The small number of
studies warrants the need for more randomised controlled trials evaluating the efficacy and safety of combination therapy.
- Troubles du métabolisme des lipides

Langue : ANGLAIS