Article

This study aimed firstly to investigate the feasibility of the study
protocol and outcome measures, secondly to obtain data in order to inform the
power calculations for a larger randomised controlled trial, and finally to
investigate if whole-body vibration (WBV) is more effective than the same
duration and intensity of standard exercises (EXE) in people with Multiple
Sclerosis (PwMS). DESIGN: Randomised controlled feasibility study. SETTING:
Outpatient MS centre. SUBJECTS: Twenty seven PwMS (age mean (SD) 48.1 (11.2))
with minimal gait impairments. INTERVENTIONS: Twelve weeks of WBV or standard
EXE, three times weekly.
MAIN MEASURES: Participants were measured with
isokinetic muscle strength, vibration threshold, Timed Up and Go test (TUG),
Mini-BESTest (MBT), 6 Minute Walk test (6MWT), Multiple Sclerosis Impact Scale 29
(MSIS 29), Modified Fatigue Impact Scale (MFIS) and Verbal Analogue scale for
sensation (VAS) pre and post 12 week intervention. RESULTS: WBV intervention was
found feasible with low drop-out rate (11.1%) and high compliance (90%). Data
suggest that a sample of 52 in each group would be sufficient to detect a
moderate effect size, with 80% power and 5% significance for 6 minute walk test.
Large effect sizes in favour of standard exercise were found for vibration
threshold at 5th metatarsophalangeal joint and heel (P=0.014, r= 0.5 and P=0.005, r=0.56 respectively).
No between group differences were found for muscle strength, balance or gait (P>0.05). CONCLUSIONS: Data suggest that the protocol
is feasible, there were no adverse effects. A trial including 120 people would be
needed to detect an effect on walking endurance.
CI - (c) The Author(s) 2015.

Langue : ANGLAIS