Article

We compared two botulinum toxin A (BoNT-A) injection frequency regimens,
12-monthly versus 4-monthly, for spastic equinus in a randomized clinical trial.
The primary outcome measure was passive ankle dorsiflexion. METHOD: Forty-two
ambulant children with spastic equinus, secondary to cerebral palsy (23 males and
19 females; mean age 3y 6mo, SD 13mo; GMFCS levels I [n=20], II [n=19], III
[n=3]) were randomized to receive either 12-monthly or 4-monthly BoNT-A
injections to the calf, over a 26-month period. Twenty-one children had spastic
hemiplegia, 21 children had spastic diplegia. A fixed 6U/kg dose of Botox was
injected into the gastrocnemius muscle of both limbs in children with diplegia
and the gastrocsoleus of the affected limb in children with hemiplegia, under
mask anaesthesia. RESULTS: Forty-two children entered the trial with 21
participants randomized to each group. There were three withdrawals and two
children received serial casting midway through the trial. There was no
significant difference in passive dorsiflexion between 12-monthly and 4-monthly
regimens (p=0.41). There were also no significant between group differences on
secondary outcome measures. There were no serious adverse events - the rate was
1.2 adverse events per child per year in the 12-monthly group and 2.2 adverse
events per child per year in the 4-monthly group. Subgroup analysis revealed a
significant difference in passive dorsiflexion between children with hemiplegia
and diplegia (p=0.01). INTERPRETATION: There was no significant difference
between 12-monthly and 4-monthly injection regimens on passive dorsiflexion or
secondary outcome measures. BoNT-A injections for spastic equinus may be
recommended on a 12-monthly basis.
CI - (c) 2015 Mac Keith Press.

Langue : ANGLAIS