Article

Previous studies suggest a higher prevalence of neurological disease within
certain ethnic communities, but have not specifically considered neuromuscular
diseases (NMDs). The aim of this study was to calculate the prevalence and
relationship of NMDs to ethnicity and deprivation status.
METHOD: We undertook a
retrospective case-note review of those younger than 16 years with a confirmed
diagnosis of NMD in a single centre in Yorkshire in 2010. RESULTS: Two-hundred
and sixty-one cases were included. The population (0-16y) in Yorkshire was 707
961. The overall prevalence was 36.9 per 100 000 (95% confidence interval [CI]
34.6-39.1). Dystrophin-related muscle disease was the most common condition, with
a prevalence of 16.9 per 100 000 males (95% CI 14.7-19.1). There was a
significant difference between ethnic groups, with a total NMD prevalence of 91.2
per 100 000 (95% CI 81.6-100.7) in the South Asian ethnic group compared with
28.7 per 100 000 (95% CI 26.4-30.9) in the White group. Prevalence of
non-dystrophin-related NMDs was four times higher in South Asian than in White
children. There was a linear relation between increased prevalence and increased
deprivation. INTERPRETATION: This study confirms higher levels of NMD,
particularly recessively inherited NMDs within the South Asian population, as
well as a link with higher deprivation. This has implications for service
provision and resource allocation.
CI - (c) 2016 Mac Keith Press.

Langue : ANGLAIS