Article

The aim of this study was to determine the effects of repeat botulinum toxin
A (BoNT-A) injections in children with spastic cerebral palsy (CP) on the basis
of a best evidence synthesis. METHOD: This study included 13 original articles
after searching the literature to retrieve information. We used the critical
review form produced by McMaster University to determine the methodological
quality of the studies, and then confirmed the levels of evidence from Sackett.
The studies were also evaluated using the International Classification of
Function, Disability and Health - Children and Youth Version (ICF-CY). RESULTS: A
total of 893 children with spastic CP who had been administered repeat BoNT-A
injections were evaluated. The evidence level was II in four of the thirteen
studies, III in four studies, and IV in five studies. The McMaster review form
score was 14 in two studies, 13 in four studies, and 12 in seven studies. The
results showed that repeat BoNT-A may be a safe and an effective approach. The
first two injections/one repeat especially relieve spasticity and improve fine
and gross motor activities. INTERPRETATION: Future studies to investigate the
effectiveness of repeat BoNT-A in children with spastic CP may be planned within
the framework of the ICF-CY to include well-designed randomized controlled trials
and those conducted on larger homogenous groups.
CI - (c) 2016 Mac Keith Press.

Langue : ANGLAIS