Article

Auditory verbal hallucinations (AVH) are among the most characteristic symptoms
of schizophrenia and have been linked to likely disturbances of structural and
functional connectivity within frontal, temporal, parietal and subcortical
networks involved in language and auditory functions.
Resting-state functional
magnetic resonance imaging (fMRI) has shown that alterations in the functional
connectivity activity of the default-mode network (DMN) may also subtend
hallucinations. Noninvasive neurostimulation techniques such as repetitive
transcranial magnetic stimulation (rTMS) have the ability to modulate activity of
targeted cortical sites and their associated networks, showing a high potential
for modulating altered connectivity subtending schizophrenia. Notwithstanding,
the clinical benefit of these approaches remains weak and variable. Further
studies in the field should foster a better understanding concerning the status
of networks subtending AVH and the neural impact of rTMS in relation with symptom
improvement. Additionally, the identification and characterization of clinical
biomarkers able to predict response to treatment would be a critical asset
allowing better care for patients with schizophrenia.
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Langue : ANGLAIS