Article

This cross-sectional investigation aimed to assess the value of non-invasive
measures of temporal respiratory-swallow coupling in individuals with ataxic
swallowing. METHOD: Twenty participants (11 males, 9 females; range 9-21y) with
ataxia telangiectasia were presented with water and pudding boluses. Their 193
swallows were compared with 2200 swallows from 82 age-matched healthy controls.
The two components of airway protection during swallowing that were analyzed
were: direction of peri-deglutitive airflow and duration of deglutitive
inhibition of respiratory airflow (DIORA). RESULTS: Safe expiratory patterns of
peri-deglutitive airflow occurred significantly less often in participants with
ataxia telangiectasia than in age-matched control participants (younger p<0.015
and older p<0.001). The frequency of an expiratory pattern of peri-deglutitive
airflow increased with age in participants in the comparison group (p=0.006), but
not in those with ataxia telangiectasia (p=0.234). With age, mean duration of
DIORA decreased in controls (p<0.001) but was unchanged in participants with
ataxia telangiectasia (p=0.164). INTERPRETATION: Non-invasive quantitative
measures of respiratory-swallow coupling capture temporal relationships that
plausibly contribute to airway compromise from dysphagia. Changes in
respiratory-swallow coupling observed with advancing age in control participants
were not seen in participants with ataxia telangiectasia. Measures of
perturbations may herald swallowing problems prior to development of pulmonary
and nutritional sequelae.
CI - (c) 2016 Mac Keith Press.
- Ataxie télangiectasie - enfant

Langue : ANGLAIS