Article

OBJECTIVE: To investigate the individual occurrence of walking-related motor
fatigue in persons with multiple sclerosis (PwMS), according to disability level
and disease phenotype.Study design This was a cross-sectional, multinational
study.Participants They were 208 PwMS from 11 centers with Expanded Disability
Status Scale (EDSS) scores up to 6.5. METHODS: The percentage change in distance
walked (distance walked index, DWI) was calculated between minute 6 and 1
(DWI(6-1)) of the 6-Minute Walk Test (6MWT). Its magnitude was used to classify
participants into 4 subgroups: (1) DWI(6-1)[>/=5%], (2) DWI(6-1)[5%; -5%], (3)
DWI(6-1)[-5%; > -15%], and (4) DWI(6-1)[</=-15%]. The latter group was labeled as
having walking-related motor fatigue. PwMS were stratified into 5 subgroups based
on the EDSS (0-2.5, 3-4, 4.5-5.5, 6, 6.5) and 3 subgroups based on MS phenotype
(relapsing remitting [RR], primary progressive [PP], and secondary progressive
[SP]). RESULTS: The DWI6-1was >/=5% in 16 PwMS (7.7%), between 5% and -5% in 70
PwMS (33.6%), between -5% and -15% in 58 PwMS (24%), and </=-15% in 64 PwMS
(30.8%). The prevalence of walking-related motor fatigue (DWI(6-1)[</=-15%]) was
significantly higher among the progressive phenotype (PP = 50% and SP = 39%; RR =
15.6%) and PwMS with higher disability level (EDSS 4.5-5.5 = 48.3%, 6 = 46.3% and
6.5 = 51.5%, compared with EDSS 0-2.5 = 7.8% and 3-4 = 16.7%;P< .05). Stepwise
multiple regression analysis indicated that EDSS, but not MS phenotype, explained
a significant part of the variance in DWI(6-1)(R(2)= 0.086;P< .001). CONCLUSION:
More than one-third of PwMS showed walking-related motor fatigue during the 6MWT,
with its prevalence greatest in more disabled persons (up to 51%) and in those
with progressive MS phenotype (up to 50%). Identification of walking-related
motor fatigue may lead to better-tailored interventions.
CI - (c) The Author(s) 2015.

Langue : ANGLAIS