Article

The aim of this study was to investigate the effects of vitamin D supplementation
on pain, quality of life, and nerve conduction studies (NCSs) in women with
chronic widespread pain (CWP) diagnosed with Vitamin D insufficiency.
Thirty-three female participants with CWP and vitamin D insufficiency were
included in this open-label trial. They were evaluated by routine NCSs in upper
and lower limbs, pain scales,
and the Nottingham Health Profile before and 8
weeks after starting vitamin D supplementation therapy.
The P-value was adjusted
to account for the number of comparisons performed in each assessment. After 8
weeks of treatment, participants reported significantly lower pain scores
(P=0.000). The total Nottingham Health Profile score and subscores for pain,
emotional reactions, and physical activity domains were significantly lower
(0.000</=P</=0.008). However, no statistically significant changes in NCSs were
detected, except trends toward increases in the amplitudes of left median and
ulnar sensory nerve potentials and a decrease in the distal latency of the right
median sensory potential (0.01</=P</=0.04). Vitamin D supplementation therapy
decreased pain and increased quality of life without significantly affecting nerve conduction in patients with CWP.

Langue : ANGLAIS