Article

OBJECTIVE: To investigate the relationship between sedentary behavior and
quality-adjusted life years (QALYs) among participants in the Osteoarthritis
Initiative. DESIGN: Longitudinal, observational design.
SETTING: Osteoarthritis
Initiative cohort. PARTICIPANTS: Individuals (N=1794) from a prospective,
multicenter longitudinal cohort were classified into quantile groups based on
average daily sedentary time (most sedentary, quartile 1 [Q1] >/=11.6h; 10.7h</=
Q2 <11.6h; 9.7h</= Q3 <10.7h; least sedentary, Q4 <9.7h). INTERVENTIONS: Not
applicable. MAIN OUTCOME MEASURES: Individual QALYs were estimated over 2 years
from the area under the curve of health-related utility scores derived from the
Medical Outcomes Study 12-Item Short-Form Health Survey versus time. The
relationship between baseline sedentary behavior and median 2-year QALYs was
estimated using quantile regression adjusted for socioeconomic factors and body
mass index. RESULTS: Lower QALYs over 2 years were more frequently found among
the most sedentary (Q1, median 1.59), and QALYs increased as time spent in
baseline sedentary behavior decreased (median QALYs for Q2, 1.64; Q3, 1.65; Q4,
1.65). The relationship of sedentary time and median QALY change was only
significant for the most sedentary Q1 group, where an additional hour of
sedentary behavior significantly reduced QALYs by -.072 (95% confidence interval,
-.121 to -.020). CONCLUSIONS: Our findings suggest that individuals with the most
extreme sedentary profiles may be vulnerable to additional losses of quality of
life if they become more sedentary. Targeting these individuals to decrease
sedentary behavior has the potential to be cost-effective.
CI - Copyright (c) 2017 American Congress of Rehabilitation Medicine. Published by
Elsevier Inc. All rights reserved.

Langue : ANGLAIS