Article

AIM: To describe accurate, standardized 1h-multimodal neurophysiological
monitoring (1h-MNM), while simultaneously recording VEEG, aEEG, and SEP-C
bilaterally from median nerves, and to collect neonatal normative SEP-C data
related to behavioural states. METHOD: Twenty healthy, term newborn infants (13
males, 7 females; gestational age 37-42wks; mean 39.6wks, standard deviation [SD]
1.3wks) underwent 1h-MNM within 2 days of life, with focus on recording of the
SEP-C (band-pass setting 1-100 Hz, rate of stimulation 1.1 Hz, 50 alternate
stimuli). RESULTS: 1h-MNM was easily obtained with identification of cervical
(N13) and cortical (N1, P1) SEP-C responses in all infants. SEP-C minimal and
maximum N1 latencies/N1-P1 amplitudes were identified, bilaterally, during
periods of spontaneous sleep active-quiet-active (AS-QS-AS) and
quiet-wakefulness. Minimal latencies and amplitudes occurred in 60% of active
sleep/quiet-wakefulness, with the maximums in 70% of quiet sleep. The SEP-C mean
values were latencies of N13=13.6ms (SD 1.4ms) and N1=33.6ms (SD 3.9ms) to 34.2ms
(SD 4.8ms) in left and right hemisphere respectively; central-conduction-time
(CCT) (N13-N1), 20.0ms (SD 4.3ms) to 20.6ms (SD 4.8ms); N1-P1 amplitude=4.6ms (SD
2.7ms) to 3.8muV (SD 2.2muV). INTERPRETATION: 1h-MNM can record simultaneously
VEEG/aEEG/SEP-C in newborn infants, showing the modulation of SEP cortical
responses in relation to behavioural states in all infants studied using an
appropriate neonatal method. We emphasize the importance of obtaining neonatal
SEP-C normative data to better identify pathological findings in neonatal brain injury.
CI - (c) 2017 Mac Keith Press.

Langue : ANGLAIS