Article

OBJECTIVE: To identify the extent to which exercise intervention studies in
multiple sclerosis rehabilitation are addressing comorbidities and if researchers
consider comorbidities as possible moderators or mediators of exercise outcomes.
METHODS: Five databases were searched from inception to January 8, 2016, for
exercise-related terms in combination with multiple sclerosis. Studies were
screened and limited to randomized control trials, full text, and English
language. We assessed whether comorbidities were excluded or included, how they
were reported and described, and if they were examined as possible moderators or
mediators of exercise outcomes. RESULTS: We reviewed 99 articles that included
various exercise interventions, where the most common were general multi-faceted
exercise training ( n=34), cardiovascular training ( n=18),
progressive-resistance training ( n=12), and balance and gait training ( n=12).
In total, 77 of 99 studies reported one or more comorbidities as an exclusion
criterion. The most commonly excluded comorbidities were cardiovascular diseases,
cognitive impairments or psychiatric disorders, and unspecified conditions or
contraindications. Only nine studies reported details on excluded participants
with comorbidities. Across studies that reported comorbidities of included
participants ( n=8), none examined comorbidities as possible moderators or
mediators of exercise outcomes. CONCLUSION:
Although a variety of exercise
interventions have positive outcomes, there is limited evidence that these
interventions are generalizable to people with multiple sclerosis who have
comorbid conditions.

Langue : ANGLAIS