Article

OBJECTIVE: To further test the validity and clinical usefulness of the steep ramp
test (SRT) in estimating exercise tolerance in cancer survivors by external
validation and extension of previously published prediction models for peak
oxygen consumption (Vo2peak) and peak power output (Wpeak). DESIGN:
Cross-sectional study. SETTING: Multicenter. PARTICIPANTS: Cancer survivors
(N=283) in 2 randomized controlled exercise trials. INTERVENTIONS: Not
applicable. MAIN OUTCOME MEASURES: Prediction model accuracy was assessed by
intraclass correlation coefficients (ICCs) and limits of agreement (LOA).
Multiple linear regression was used for model extension. Clinical performance was
judged by the percentage of accurate endurance exercise prescriptions. RESULTS:
ICCs of SRT-predicted Vo2peak and Wpeak with these values as obtained by the
cardiopulmonary exercise test were .61 and .73, respectively, using the
previously published prediction models. 95% LOA were +/-705mL/min with a bias of
190mL/min for Vo2peak and +/-59W with a bias of 5W for Wpeak. Modest improvements
were obtained by adding body weight and sex to the regression equation for the
prediction of Vo2peak (ICC, .73; 95% LOA, +/-608mL/min) and by adding age,
height, and sex for the prediction of Wpeak (ICC, .81; 95% LOA, +/-48W). Accuracy
of endurance exercise prescription improved from 57% accurate prescriptions to
68% accurate prescriptions with the new prediction model for Wpeak. CONCLUSIONS:
Predictions of Vo2peak and Wpeak based on the SRT are adequate at the group
level, but insufficiently accurate in individual patients. The multivariable
prediction model for Wpeak can be used cautiously (eg, supplemented with a Borg
score) to aid endurance exercise prescription.
CI - Copyright (c) 2017 American Congress of Rehabilitation Medicine. Published by
Elsevier Inc. All rights reserved.

Langue : ANGLAIS