Article

Endovascular thrombectomy has become the reference
therapy for patients with large vessel occlusion (LVO).
However, no meta-analysis
including the THRACE Trial has yet been reported. Thus, the present review
assessed the outcomes of stent retriever thrombectomy added to medical care
compared with medical care alone in LVO patients. METHODS: A systematic review was conducted of all randomized controlled trials (RCTs)
examining stent retrievers added to medical care vs medical care alone in the
MEDLINE, Embase and Web of Science databases. Meta-analyses of 90-day functional
outcomes and mortality, and the occurrence of symptomatic intracranial hemorrhage
(sICH), with thrombectomy plus medical care vs medical care alone were performed.
RESULTS: Six multicenter RCTs involving 1673 patients were included. Successful
recanalization (modified thrombolysis in cerebral ischemia grades 2b-3) was seen
in 71% of patients (95% CI: 62-79%) after thrombectomy. These patients also had
significantly higher rates of 90-day functional independence (mRS scores 0-2)
compared with those receiving medical care only (OR: 2.14, 95% CI: 1.72-2.67;
P<0.00001), as well as excellent outcomes (mRS scores 0-1, OR: 2.05, 95% CI:
1.58-2.67; P<0.00001). Also, the rate of functional independence was higher (OR:
2.39, 95% CI: 1.88-3.04; P<0.00001) in the subgroup analysis without the THRACE
Trial. The effect of endovascular therapy on 90-day mortality was inconclusive
(OR: 0.82, 95% CI: 0.62-1.07; P=0.15), and there was no increased occurrence of
sICH (OR: 1.11, 95% CI: 0.66-1.88; P=0.70). CONCLUSION: Stent retriever
thrombectomy added to medical care improved 90-day functional outcomes compared
with medical care alone with no impact on mortality and risk of sICH in LVO patients.
CI - Copyright (c) 2018. Published by Elsevier Masson SAS.

Langue : ANGLAIS