Article

Atypical idiopathic inflammatory demyelinating disorders (IIDDs) of the brain
have long been known to be disorders closely related to multiple sclerosis (MS),
despite having distinctive clinical and radiological characteristics. Originally,
they mostly corresponded to acute-onset variants of MS that classically had poor
prognoses, such as Balo's concentric sclerosis, Marburg variant of MS and
Schilder's disease, and their relationship with MS was based on their shared
pathological findings and the co-occurrence of these variants in patients with
typical MS. More recently, other atypical disorders, such as solitary sclerosis,
have also been described as belonging to the MS spectrum, raising the question of
their links with MS. Meanwhile, multiple MS mimics have been described and need
to be considered in the differential diagnosis of MS. In addition, thorough
characterization of these atypical entities, including advanced MRI and
biological studies, is now warranted to further improve their management.
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Langue : ANGLAIS