Article

AIM: To systematically review literature on health-related quality of life
(HRQoL) of children and adolescents (</=18yo) with cerebral palsy (CP) from low-
and middle-income countries (LMICs) to identify trends in HRQoL and areas for
future research. METHOD:
We systematically reviewed six key bibliographic
databases and two reviewers independently screened results. Peer-reviewed
original articles examining HRQoL of children from LMICs were eligible. RESULTS:
A total of 22 524 papers were identified, of which 16, from eight LMICs, were
included. Four measures of HRQoL were used; Child Health Questionnaire Parent
Form 50 (n=5); Paediatric Quality of Life Inventory 3.0 and 4.0 (n=4); CP Quality
of Life Questionnaire for Children (n=4); Lifestyle Assessment Questionnaire CP
(n=3). Children with CP from LMICs (n=1579; 2-18y) had significantly poorer HRQoL
on all instrument dimensions when compared to age-matched controls (p<0.003) and
on all except two dimensions when compared to peers in high-income countries
(p<0.001). Physical well-being dimensions of HRQoL were poorest overall and
associated with impaired motor function. INTERPRETATION: Research to improve
HRQoL in LMICs is required and should address all aspects of HRQoL. Future
research is recommended to incorporate multi-respondent assessment, utilize both
general and CP-specific measures of HRQoL, and delineate adolescents as a unique
cohort. What this paper adds Children with cerebral palsy from low- and
middle-income countries are at high risk of poor health-related quality of life
(HRQoL). Physical well-being was poorest dimension of HRQoL and associated with
impaired motor function.
CI - (c) 2018 Mac Keith Press.

Langue : ANGLAIS