Article

OBJECTIVES: (1) To determine the prevalence of sarcopenia in older men with
peripheral arterial disease (PAD); (2) to compare a subgroup of the group with
age-, race-, sex-, and body mass index (BMI)-matched non-PAD control
counterparts, and (3) to compare the functional status of those with PAD with and
without sarcopenia. DESIGN: Cohort study. SETTING: Medical center. PARTICIPANTS:
Sedentary community-dwelling men (N=108; age, >50y) with a confirmed diagnosis of
PAD (44% blacks; BMI, 27.8+/-0.4kg/m(2); ankle-brachial index, .62+/-.01).
INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURES: Dual-energy x-ray
absorptiometry scans were used to assess appendicular lean mass and determine the
prevalence of sarcopenia by/height(2). Treadmill tests were used to determine
claudication onset time, peak walking time, and claudication recovery time.
6-Minute walk distance was also measured. RESULTS: Sarcopenia prevalence in our
PAD cohort was 25%. The PAD subgroup (n=42) matched with control counterparts in
terms of race, sex, age, and BMI had higher prevalence rates than did their
non-PAD counterparts (23.8% vs 2.4%; P<.05). Individuals with sarcopenia (n=28)
had a shorter 6-minute walk distance (326+/-18.8m vs 380+/-9.7m; P<.05) and
higher claudication recovery time (592+/-98s vs 395+/-29s; P<.05) than did
individuals with PAD but without sarcopenia (n=80). There was no difference in
claudication onset time or peak walking time between the PAD groups. CONCLUSIONS:
Men with PAD demonstrate a high prevalence of sarcopenia. Those with sarcopenia
and PAD demonstrate decreased mobility function.
CI - Published by Elsevier Inc.

Langue : ANGLAIS