Article

The Hoorn Study - AIMS: To investigate the associations of HbA1c, fasting glucose, and postload
plasma glucose with 10-year fatal and non-fatal cardiovascular disease (CVD) and
all-cause mortality in Caucasian individuals between 50 and 75 years of age
without diabetes. METHOD : The 10-year risk of all-cause mortality and
CVD in relation to HbA1cand glucose levels was assessed with Cox survival
analysis in 1674 non-diabetic individuals of a population-based cohort (Hoorn
Study). Analyses were stratified according to sex and adjustments were made for
age and known CVD risk factors. After full adjustment, HbA1c levels >/= 6.0% were
significantly associated with an increased risk of non-fatal CVD compared with
the lowest category of HbA1c (</= 5.1%) in women [hazards ratio (HR) 2.27
(1.24-4.14)]. In addition, HbA1c as a continuous variable was significantly
related to non-fatal CVD in both men [HR 1.40 (1.01-1.95)] and women [HR 2.41
(1.51-3.83)]. The relationships of HbA1 c with fatal CVD and all-cause mortality
were explained by traditional CVD risk factors in both the sexes, along with the
associations between fasting or postload plasma glucose and any of the outcome
measures. CONCLUSION: In Caucasian men and especially in women between 50 and 75
years of age who are without diabetes, high HbA1c levels are associated with
increased risk of future non-fatal CVD, independent of other CVD risk factors.

Langue : ANGLAIS