Article

Multiple sclerosis (MS) is a chronic disease in which disability progresses over
time. Progressive forms of MS have a poor prognosis, are associated with greater
levels of disability and, unfortunately, are unresponsive to current treatments.
Here, we have reviewed the management of 100 patients with MS. The majority of
these patients had progressive disease, Expanded Disability Status Scale scores
>6, and extensive medical complications. A significant number of patients in this
cohort were also treated with MS disease-modifying agents that lack efficacy in
patients with progressive disease. Although these drugs are relatively safe,
their use here is significantly costly to the healthcare system, with limited
benefit to patients. We suggest that these drugs be discontinued in these
patients and resources be directed toward symptomatic treatment, rehabilitation
needs, and management of medical complications until drugs with proven efficacy
become available.

Langue : ANGLAIS