Article

Osteoarthritis patients with diabetes who receive total knee arthroplasty are
more vulnerable to complications, including aseptic loosening and need for
revision surgery. To elucidate mechanisms related to arthroplasty failure in
diabetes, we examined serum and synovial fluid markers as well as collagen
crosslinks in bone and cartilage of 20 patients (10 with diabetes, 10 controls
without) undergoing this procedure. Hemoglobin A1c, body mass index, bone
alkaline phosphatase, leptin, osteocalcin, and pyridinium were analyzed along
with tissue content of the crosslinks hydroxylysylpyridinoline,
lysylpyridinoline, and pentosidine. Pentosidine levels in tissue specimens from
diabetic subjects were higher than in control subjects. Osteocalcin levels
negatively correlated with hydroxylysylpyridinoline levels in cartilage.
Osteocalcin levels also negatively correlated with pentosidine levels in
cartilage, but only in subjects with diabetes. This study suggests potential
metabolic mechanisms for arthroplasty failure in patients with diabetes.

Langue : ANGLAIS