Article

OBJECTIVE: To examine the relation between diffusion tensor imaging (DTI) of the
corpus callosum and postconcussion symptom reporting following mild traumatic
brain injury (MTBI). PARTICIPANTS: Sixty patients with MTBI and 34 patients with
orthopedic/soft-tissue injuries (Trauma Controls) prospectively enrolled from
consecutive admissions to a level 1 trauma center. PROCEDURE: Diffusion tensor
imaging of the corpus callosum was undertaken using a Phillips 3T scanner at 6 to
8 weeks postinjury. Participants also completed a postconcussion symptom
checklist. The MTBI group was divided into 2 subgroups based on the International
Classification of Diseases, Tenth Revision symptom criteria for postconcussion
disorder (PCD): PCD Present (n = 21), PCD Absent (n = 39). MAIN OUTCOME MEASURES:
Measures of fractional anisotropy and mean diffusivity for the genu, body, and
splenium of the corpus callosum. Participants also completed the British Columbia
Post-Concussion Symptom Inventory. RESULTS: The MTBI group reported more
postconcussion symptoms than the trauma controls. There were no significant
differences between MTBI and trauma control groups on all DTI measures. In the
MTBI sample, there were no significant differences on all DTI measures between
those who did and did not meet the International Classification of Diseases,
Tenth Revision research criteria for postconcussion disorder. CONCLUSIONS: These
data do not support an association between white matter integrity in the corpus
callosum and self-reported postconcussion syndrome 6 to 8 weeks post-MTBI.

Langue : ANGLAIS