Article

Only a few studies have identified prognostic factors indicating risk
of future knee arthroplasty in patients with osteoarthritis (OA) of the knee. The
Osteoarthritis Initiative (OAI) is a National Institutes of Health and privately
funded cohort study of 4796 persons with or at high risk of knee OA. The OAI is
ideally suited to a more extensive study of knee arthroplasty prognostic factors
than has been undertaken. The purpose of our study was to identify patient
factors which predict rapid progression to knee arthroplasty, defined as
arthroplasty within three years of baseline data collection. METHODS: We used
alternating logistic regression models to analyze complete three year follow-up
data from the OAI on 4670 persons with, or at risk for knee OA, aged 45 to 79
years during the years 2004 to 2008. RESULTS: A total of 128 knees (116 persons)
underwent knee arthroplasty during the study period. After adjusting for known
prognostic factors, several previously unidentified predictors of future knee
arthroplasty were found including past history of knee surgery (RR=2.04, 95%
CI=1.33, 3.13), knee flexion contracture in degrees (RR=1.06, 95% CI=1.02, 1.11)
and pain, on a 0 to 10 scale, with active knee flexion (RR=1.58, 95% CI=1.04,
2.39). DISCUSSION/CONCLUSIONS: This study identifies new and easily measured
clinical variables that are associated with more rapid progression to
arthroplasty. The data may help to inform both physicians and patients of medical
history and clinical examination findings most highly associated with short-term
arthroplasty.
CI - Copyright (c) 2011 Societe francaise de rhumatologie. Published by Elsevier SAS.
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Langue : ANGLAIS